Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus
Identifieur interne : 001A47 ( Main/Exploration ); précédent : 001A46; suivant : 001A48Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus
Auteurs : Kai-Wen Cheng [Taïwan] ; Shu-Chun Cheng [Taïwan] ; Wei-Yi Chen [Taïwan] ; Min-Han Lin [Taïwan] ; Shang-Ju Chuang [Taïwan] ; I-Hsin Cheng [Taïwan] ; Chiao-Yin Sun [Taïwan] ; Chi-Yuan Chou [Taïwan]Source :
- Antiviral Research [ 0166-3542 ] ; 2014.
Descripteurs français
- KwdFr :
- Acide mycophénolique (pharmacologie), Antiviraux (pharmacologie), Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (enzymologie), Cysteine endopeptidases, Cysteine proteases (), Cysteine proteases (métabolisme), Inhibiteurs de la cystéine protéinase (pharmacologie), Modèles moléculaires, Protéines virales (antagonistes et inhibiteurs), Synergie des médicaments, Tioguanine (pharmacologie), Virus du SRAS (), Virus du SRAS (enzymologie).
- MESH :
- antagonistes et inhibiteurs : Protéines virales.
- enzymologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- métabolisme : Cysteine proteases.
- pharmacologie : Acide mycophénolique, Antiviraux, Inhibiteurs de la cystéine protéinase, Tioguanine.
- Coronavirus du syndrome respiratoire du Moyen-Orient, Cysteine endopeptidases, Cysteine proteases, Modèles moléculaires, Synergie des médicaments, Virus du SRAS.
English descriptors
- KwdEn :
- Antiviral Agents (pharmacology), Cysteine Endopeptidases, Cysteine Proteases (chemistry), Cysteine Proteases (metabolism), Cysteine Proteinase Inhibitors (pharmacology), Drug Synergism, Mercaptopurine (pharmacology), Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (enzymology), Models, Molecular, Mycophenolic Acid (pharmacology), SARS Virus (drug effects), SARS Virus (enzymology), Thioguanine (pharmacology), Viral Proteins (antagonists & inhibitors).
- MESH :
- chemical , antagonists & inhibitors : Viral Proteins.
- chemical , chemistry : Cysteine Proteases.
- chemical , metabolism : Cysteine Proteases.
- chemical , pharmacology : Antiviral Agents, Cysteine Proteinase Inhibitors, Mercaptopurine, Mycophenolic Acid, Thioguanine.
- chemical : Cysteine Endopeptidases.
- drug effects : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- enzymology : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- Drug Synergism, Models, Molecular.
Abstract
6-Mercaptopurine and 6-thioguanine are competitive inhibitors of SARS-CoV and MERS-CoV papain-like proteases. Mycophenolic acid can noncompetitively inhibit papain-like protease of MERS-CoV, while cannot inhibit that of SARS-CoV. 6-Mercaptopurine/6-thioguanine and mycophenolic acid synergistically inhibit MERS-CoV papain-like protease. The three drugs with inhibitory effect for MERS-CoV papain-like protease can be used as lead compounds for drug development.
Url:
DOI: 10.1016/j.antiviral.2014.12.011
PubMed: 25542975
PubMed Central: 7113672
Affiliations:
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Le document en format XML
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id="af010">Department of Nephrology, Chang-Gung Memorial Hospital, Keelung 204, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Nephrology, Chang-Gung Memorial Hospital, Keelung 204</wicri:regionArea><wicri:noRegion>Keelung 204</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Wei Yi" sort="Chen, Wei Yi" uniqKey="Chen W" first="Wei-Yi" last="Chen">Wei-Yi Chen</name><affiliation wicri:level="1"><nlm:aff id="af015">Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Min Han" sort="Lin, Min Han" uniqKey="Lin M" first="Min-Han" last="Lin">Min-Han Lin</name><affiliation wicri:level="1"><nlm:aff id="af005">Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation></author><author><name sortKey="Chuang, Shang Ju" sort="Chuang, Shang Ju" uniqKey="Chuang S" first="Shang-Ju" last="Chuang">Shang-Ju Chuang</name><affiliation wicri:level="1"><nlm:aff id="af005">Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation></author><author><name sortKey="Cheng, I Hsin" sort="Cheng, I Hsin" uniqKey="Cheng I" first="I-Hsin" last="Cheng">I-Hsin Cheng</name><affiliation wicri:level="1"><nlm:aff id="af015">Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Chiao Yin" sort="Sun, Chiao Yin" uniqKey="Sun C" first="Chiao-Yin" last="Sun">Chiao-Yin Sun</name><affiliation wicri:level="1"><nlm:aff id="af010">Department of Nephrology, Chang-Gung Memorial Hospital, Keelung 204, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Nephrology, Chang-Gung Memorial Hospital, Keelung 204</wicri:regionArea><wicri:noRegion>Keelung 204</wicri:noRegion></affiliation></author><author><name sortKey="Chou, Chi Yuan" sort="Chou, Chi Yuan" uniqKey="Chou C" first="Chi-Yuan" last="Chou">Chi-Yuan Chou</name><affiliation wicri:level="1"><nlm:aff id="af005">Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (pharmacology)</term><term>Cysteine Endopeptidases</term><term>Cysteine Proteases (chemistry)</term><term>Cysteine Proteases (metabolism)</term><term>Cysteine Proteinase Inhibitors (pharmacology)</term><term>Drug Synergism</term><term>Mercaptopurine (pharmacology)</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>Middle East Respiratory Syndrome Coronavirus (enzymology)</term><term>Models, Molecular</term><term>Mycophenolic Acid (pharmacology)</term><term>SARS Virus (drug effects)</term><term>SARS Virus (enzymology)</term><term>Thioguanine (pharmacology)</term><term>Viral Proteins (antagonists & inhibitors)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide mycophénolique (pharmacologie)</term><term>Antiviraux (pharmacologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (enzymologie)</term><term>Cysteine endopeptidases</term><term>Cysteine proteases ()</term><term>Cysteine proteases (métabolisme)</term><term>Inhibiteurs de la cystéine protéinase (pharmacologie)</term><term>Modèles moléculaires</term><term>Protéines virales (antagonistes et inhibiteurs)</term><term>Synergie des médicaments</term><term>Tioguanine (pharmacologie)</term><term>Virus du SRAS ()</term><term>Virus du SRAS (enzymologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cysteine Proteases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cysteine Proteases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Cysteine Proteinase Inhibitors</term><term>Mercaptopurine</term><term>Mycophenolic Acid</term><term>Thioguanine</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Cysteine Endopeptidases</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cysteine proteases</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acide mycophénolique</term><term>Antiviraux</term><term>Inhibiteurs de la cystéine protéinase</term><term>Tioguanine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Synergism</term><term>Models, Molecular</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Cysteine endopeptidases</term><term>Cysteine proteases</term><term>Modèles moléculaires</term><term>Synergie des médicaments</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label><p id="p0090">6-Mercaptopurine and 6-thioguanine are competitive inhibitors of SARS-CoV and MERS-CoV papain-like proteases.</p></list-item><list-item id="o0010"><label>•</label><p id="p0095">Mycophenolic acid can noncompetitively inhibit papain-like protease of MERS-CoV, while cannot inhibit that of SARS-CoV.</p></list-item><list-item id="o0015"><label>•</label><p id="p0100">6-Mercaptopurine/6-thioguanine and mycophenolic acid synergistically inhibit MERS-CoV papain-like protease.</p></list-item><list-item id="o0020"><label>•</label><p id="p0105">The three drugs with inhibitory effect for MERS-CoV papain-like protease can be used as lead compounds for drug development.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Anand, K" uniqKey="Anand K">K. 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Rademann</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R. Hilgenfeld</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Cheng, Kai Wen" sort="Cheng, Kai Wen" uniqKey="Cheng K" first="Kai-Wen" last="Cheng">Kai-Wen Cheng</name></noRegion><name sortKey="Chen, Wei Yi" sort="Chen, Wei Yi" uniqKey="Chen W" first="Wei-Yi" last="Chen">Wei-Yi Chen</name><name sortKey="Cheng, I Hsin" sort="Cheng, I Hsin" uniqKey="Cheng I" first="I-Hsin" last="Cheng">I-Hsin Cheng</name><name sortKey="Cheng, Shu Chun" sort="Cheng, Shu Chun" uniqKey="Cheng S" first="Shu-Chun" last="Cheng">Shu-Chun Cheng</name><name sortKey="Chou, Chi Yuan" sort="Chou, Chi Yuan" uniqKey="Chou C" first="Chi-Yuan" last="Chou">Chi-Yuan Chou</name><name sortKey="Chuang, Shang Ju" sort="Chuang, Shang Ju" uniqKey="Chuang S" first="Shang-Ju" last="Chuang">Shang-Ju Chuang</name><name sortKey="Lin, Min Han" sort="Lin, Min Han" uniqKey="Lin M" first="Min-Han" last="Lin">Min-Han Lin</name><name sortKey="Sun, Chiao Yin" sort="Sun, Chiao Yin" uniqKey="Sun C" first="Chiao-Yin" last="Sun">Chiao-Yin Sun</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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